[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

Base Information

Chemical Name:[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester
CAS No.:1313042-28-2
Molecular Formula:C₂₀H₂₄N₂O₅
Molecular Weight:372.421
Hs Code.:

Synonyms:[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

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Chemical Property of [4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

Chemical Property:

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Technology Process of [4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

There total 4 articles about [4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313042-27-1
[2-bromo-4-(tert-butoxycarbonylamino-methyl)-phenoxy]-acetic acid methyl ester

: 1692-15-5
4-pyridylboronic acid

: 1313042-28-2
[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 4h;

Reference yield:

: 696-60-6
4-aminomethylphenol

: 1313042-28-2
[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; hydrogen bromide / acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: caesium carbonate / tetrahydrofuran / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

With hydrogen bromide; bromine; caesium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid;

Reference yield:

: 63491-89-4
4-(aminomethyl)-2-bromophenol hydrogenbromide salt

: 1313042-28-2
[4-(tert-butoxycarbonylamino-methyl)-2-pyridin-4-yl-phenoxy]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: caesium carbonate / tetrahydrofuran / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;