2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

Base Information

• Chemical Name: 2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide
• CAS No.: 1253186-97-8
• Molecular Formula: C₁₈H₁₁F₅IN₃O
• Molecular Weight: 507.201

Synonyms:2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

Chemical Property of 2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

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Technology Process of 2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

There total 1 articles about 2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(bromomethyl)-4-iodo-2-(trifluoromethyl)benzene (1253188-93-0) + 2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide (1249343-86-9) → 2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (1253186-97-8)

Guidance literature:

2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.25h;

1-(bromomethyl)-4-iodo-2-(trifluoromethyl)benzene; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (1253186-97-8) + cyclopropylboronic acid (411235-57-9) → N-(1-{[4-cyclopropyl-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-2,6-difluorobenzamide (1253187-01-7)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; Inert atmosphere;

Reference yield:

2,6-difluoro-N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (1253186-97-8) + 2-methylpropyl zinc bromide → 2,6-difluoro-N-(1-{[4-(2-methylpropyl)-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (1253186-99-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 - 80 ℃; Inert atmosphere;

upstream raw materials:

1-(bromomethyl)-4-iodo-2-(trifluoromethyl)benzene

2,6-difluoro-N-(1H-pyrazol-3-yl)benzamide

Downstream raw materials:

2,6-difluoro-N-(1-{[4-(2-methylpropyl)-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

N-(1-{[4-cyclopropyl-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-2,6-difluorobenzamide

2,6-difluoro-N-(1-{[4-methyl-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

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