Technology Process of (S)-(+)-ethyl 2-methyl-5-phenylpentanoate
There total 10 articles about (S)-(+)-ethyl 2-methyl-5-phenylpentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sulfuric acid;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium; diisopropylamine; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 0.5 h / -20 - 20 °C
1.2: 2 h / 0 - 20 °C
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
3.1: tetrahydrofuran / 40 h / 48 °C
4.1: sulfuric acid / water; 1,4-dioxane / 80 °C
5.1: sulfuric acid / Reflux
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: -78 - 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: dihydrogen peroxide; lithium hydroxide / water / 4 h / 0 °C
4.1: sulfuric acid / Reflux
With
n-butyllithium; sulfuric acid; dihydrogen peroxide; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; water;
