tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

Base Information

Chemical Name:tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)
CAS No.:262863-50-3
Molecular Formula:C₂₀H₂₇ClN₆O₇P₂
Molecular Weight:560.871
Hs Code.:

Synonyms:tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

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Chemical Property of tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

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Technology Process of tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

There total 6 articles about tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 262863-47-8
(2-chloro-6-methylamino-purin-9-yl)-acetic acid

: 262863-45-6
5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester

: 262863-50-3
tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1021/jm9905211

Reference yield:

: 51760-20-4
1,3-bis-bromomethyl-5-nitro-benzene

: 262863-50-3
tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 6 h / 80 °C

2: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760.05 Torr

3: 82 percent / EDAC / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: phosphorylation / 2: catalytic reduction / 3: Acylation;
DOI:10.1021/jm9905211

Reference yield:

: 71176-55-1
5-nitro-m-xylene-(α,α')-diol

: 262863-50-3
tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / CBr₄; Ph₃P / diethyl ether / 12 h / 25 °C

2: 94 percent / 6 h / 80 °C

3: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h / 25 °C / 760.05 Torr

4: 82 percent / EDAC / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

With carbon tetrabromide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; 10percent Pd/C; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Bromination / 2: phosphorylation / 3: catalytic reduction / 4: Acylation;
DOI:10.1021/jm9905211