5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester

Base Information

• Chemical Name: 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester
• CAS No.: 262863-45-6
• Molecular Formula: C₁₂H₂₁NO₆P₂
• Molecular Weight: 337.249
• Mol file: 262863-45-6.mol

Synonyms:5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester

Chemical Property of 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester

There total 4 articles about 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-nitro-m-xylylene bisphosphonic acid tetramethyl ester (262863-44-5) → 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester (262863-45-6)

Guidance literature:

With hydrogen; 10percent Pd/C; In methanol; at 25 ℃; for 1h; under 760.051 Torr;

DOI:10.1021/jm9905211

Reference yield:

1,3-bis-bromomethyl-5-nitro-benzene (51760-20-4) → 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester (262863-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.10 g / 5 h / Heating

2: 85 percent / H₂ / Pd/C / 15 h / atmospheric pressure

With hydrogen; palladium on activated charcoal; 1: Arbuzov reaction;

DOI:10.1021/ja0560229

Reference yield:

5-nitro-m-xylene (99-12-7) → 5-amino-m-xylylenebis(phosphonic acid) tetramethyl ester (262863-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide; α,α'-azobisisobutyronitrile / CCl4 / 13 h / Heating

2: 4.10 g / 5 h / Heating

3: 85 percent / H₂ / Pd/C / 15 h / atmospheric pressure

With N-Bromosuccinimide; azobisisobutyronitrile; hydrogen; palladium on activated charcoal; In tetrachloromethane; 2: Arbuzov reaction;

DOI:10.1021/ja0560229

upstream raw materials:

5-nitro-m-xylylene bisphosphonic acid tetramethyl ester

5-nitro-m-xylene

1,3-bis-bromomethyl-5-nitro-benzene

5-nitro-m-xylene-(α,α')-diol

Downstream raw materials:

tetramethyl (2-chloro-6-methylamino-purin-9-yl)-acetaminophenyl-3',5'-bis(methylphosphonate)

1-aminobenzene-3,5-bis(methylphosphonic acid)

5-[4-(benzyloxycarbonylamino)butyrylamino]-m-xylylenebis(phosphonic acid) tetramethyl ester