Cyclopentanecarbonitrile, 2-amino- (9CI)

Base Information

• Chemical Name: Cyclopentanecarbonitrile, 2-amino- (9CI)
• CAS No.: 80501-45-7
• Molecular Formula: C6H10 N2
• Molecular Weight: 110.159
• Hs Code.: 2926909090
• Mol file: 80501-45-7.mol

Synonyms:2-Aminocyclopentane-1-carbonitrile

Chemical Property of Cyclopentanecarbonitrile, 2-amino- (9CI)

Chemical Property:

• Melting Point: 147 °C
• Boiling Point: 225.4±33.0 °C(Predicted)
• PKA: 9.47±0.40(Predicted)
• PSA: 49.81000
• Density: 1.02±0.1 g/cm3(Predicted)
• LogP: 1.33768
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

2-aminocyclopentanecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarbonitrile, 2-amino- (9CI)

There total 3 articles about Cyclopentanecarbonitrile, 2-amino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-amino-1-cyanocyclopentene (2941-23-3) → 2-amino-cyclopentanecarbonitrile (80501-45-7,874294-11-8,874293-75-1)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In methanol; for 3h;

DOI:10.1139/v99-216

Reference yield: 65.0%

2-iminocyclopentanecarbonitrile (2321-76-8) → 2-amino-cyclopentanecarbonitrile (80501-45-7,874294-11-8,874293-75-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃; for 3h;

DOI:10.1021/jf062845l

Reference yield:

hexanedinitrile (111-69-3) → 2-amino-cyclopentanecarbonitrile (80501-45-7,874294-11-8,874293-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / NaH / tetrahydrofuran

2: 65 percent / NaHB(OAc)3; acetic acid / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jf062845l

upstream raw materials:

2-amino-1-cyanocyclopentene

2-iminocyclopentanecarbonitrile

hexanedinitrile

Downstream raw materials:

2-(aminomethyl)-cyclopentylamine

2-((6-chloropyridin-3-yl)methylamino)cyclopentanecarbonitrile

tert-butyl (2-cyanocyclopentyl)carbamate

trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

Refernces

• 1、 Tian, Zhongzhen,Jiang, Zhaoxing,Li, Zhong,Song, Gonghua,Huang, Qingchun. "Syntheses and biological activities of octahydro-1H-cyclopenta[d]pyrimidine derivatives". . p. 143 - 147. Retrieved 2008/02/03.
• 2、 Atay, Ergun,Blagoeva, Iva B.,Chubb, Francis L.,Edward, John T.,Pojarlieff, Ivan G.,Toteva, Maria M.. "Assisted hydrolysis of cis-2-(3-phenylthioureido)cyclopentane-carbonitrile in alkaline solution. Solvent dependent switch from hydrolysis to rearrangement of the iminothiooxopyrimidine intermediate". . p. 84 - 94. Retrieved 2007/10/03.