trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

Base Information

Chemical Name:trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile
CAS No.:1418199-98-0
Molecular Formula:C₂₂H₂₁N₅O₃S
Molecular Weight:435.506
Hs Code.:

Synonyms:trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

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Chemical Property of trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

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Technology Process of trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

There total 5 articles about trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 598-81-2
(R)-lactamide

: trans-2-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarbonitrile

: 1418199-98-0
trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

Guidance literature:: (R)-lactamide; With triethyloxonium fluoroborate; In tetrahydrofuran; at 25 ℃; for 1.5h;

trans-2-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarbonitrile; In tetrahydrofuran; at 80 ℃; for 0.5h;

Reference yield:

: trans-2-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarbonitrile

: 1418199-98-0
trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h / 50 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 1.5 h / 25 °C

2.2: 0.5 h / 80 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; In tetrahydrofuran; ethanol;

Reference yield:

: 2321-76-8
2-iminocyclopentanecarbonitrile

: 1418199-98-0
trans-2-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium cyanoborohydride / methanol / 0.5 h / 20 - 30 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 90 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h / 50 °C

4.1: triethyloxonium fluoroborate / tetrahydrofuran / 1.5 h / 25 °C

4.2: 0.5 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol;