imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester

Base Information

• Chemical Name: imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester
• CAS No.: 1181364-55-5
• Molecular Formula: C₁₂H₁₁FN₂O₂
• Molecular Weight: 234.23
• Mol file: 1181364-55-5.mol

Synonyms:imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester

Chemical Property of imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester

There total 2 articles about imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1'-carbonyldiimidazole (530-62-1) + (1S)-1-(2-fluorophenyl)ethanol (171032-87-4) → imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester (1181364-55-5)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 4h;

Reference yield:

2'-Fluoroacetophenone (445-27-2) → imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester (1181364-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (R)-methyl oxazaborolidine; N,N-diethylaniline; diborane / tert-butyl alcohol / 1 h / 45 °C

2: tetrahydrofuran / 4 h / 50 °C

With (R)-methyl oxazaborolidine; N,N-diethylaniline; diborane; In tetrahydrofuran; tert-butyl alcohol;

Reference yield: 84.5%

imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester (1181364-55-5) + (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride (6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5) → JN 403 (942606-12-4)

Guidance literature:

(S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride; With n-butyllithium; In tetrahydrofuran; hexane; at -5 - 20 ℃;

imidazole-1-carboxylic acid (S)-1-(2-fluorophenyl)ethyl ester; In tetrahydrofuran; hexane; at 0 - 58 ℃;

DOI:10.1080/00397910802663378

upstream raw materials:

1,1'-carbonyldiimidazole

(1S)-1-(2-fluorophenyl)ethanol

2'-Fluoroacetophenone

Downstream raw materials:

JN 403