3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

Base Information

Chemical Name:3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole
CAS No.:1339110-78-9
Molecular Formula:C₁₇H₁₅F₃N₂
Molecular Weight:304.315
Hs Code.:

Synonyms:3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

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Chemical Property of 3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

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Technology Process of 3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

There total 5 articles about 3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1339110-40-5
(E)-1-(but-1-en-3-ynyl)-2-trifluoromethylbenzene

: 100-63-0
phenylhydrazine

: 1339110-78-9
3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: With zinc trifluoromethanesulfonate; In toluene; at 150 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1039/c1cc14850h

Reference yield:

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 1339110-78-9
3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / ethylenediamine; mineral oil / 0 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 0.5 h / 0 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium t-butanolate / tetrahydrofuran / 0.33 h / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: zinc trifluoromethanesulfonate / toluene / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With manganese(IV) oxide; zinc trifluoromethanesulfonate; sodium hydride; diisobutylaluminium hydride; sodium t-butanolate; In tetrahydrofuran; dichloromethane; ethylenediamine; toluene; mineral oil;
DOI:10.1039/c1cc14850h

Reference yield:

: trans-3-(2-trifluoromethylphenyl)-2-propen-1-ol

: 1339110-78-9
3-methyl-1-phenyl-5-(2-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium t-butanolate / tetrahydrofuran / 0.33 h / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: zinc trifluoromethanesulfonate / toluene / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With manganese(IV) oxide; zinc trifluoromethanesulfonate; sodium t-butanolate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1039/c1cc14850h