(-)-menthyl (Rp)-mesitylphosphinate

Base Information

• Chemical Name: (-)-menthyl (Rp)-mesitylphosphinate
• CAS No.: 1061745-76-3
• Molecular Formula: C₁₉H₃₁O₂P
• Molecular Weight: 322.428
• Mol file: 1061745-76-3.mol

Synonyms:(-)-menthyl (Rp)-mesitylphosphinate

Chemical Property of (-)-menthyl (Rp)-mesitylphosphinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-menthyl (Rp)-mesitylphosphinate

There total 2 articles about (-)-menthyl (Rp)-mesitylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,5R)-(-)-menthyl phosphorodichloridite (95456-31-8) + 2-mesitylmagnesium bromide (2633-66-1) → C19H31O2P (1061745-76-3) + (-)-menthyl (Rp)-mesitylphosphinate (1061745-76-3)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja804412k

Reference yield:

(1R,2S,5R)-(-)-menthyl phosphorodichloridite (95456-31-8) + 2-mesitylmagnesium bromide (2633-66-1) → C19H31O2P (1061745-76-3) + (-)-menthyl (Rp)-mesitylphosphinate (1061745-76-3)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja804412k

Reference yield: 93.0%

(-)-menthyl (Rp)-mesitylphosphinate (1061745-76-3) + phenyllithium (591-51-5) → (Sp)-mesitylphenylphosphine oxide (98934-20-4,1061745-96-7,1061746-09-5)

Guidance literature:

In diethyl ether; at -80 ℃; for 17h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/ja804412k

upstream raw materials:

(1R,2S,5R)-(-)-menthyl phosphorodichloridite

2-mesitylmagnesium bromide

Downstream raw materials:

(Sp)-mesitylphenylphosphine oxide

(-)-menthyl mesityl-2-hydroxy-5-trifluoromethyl phenyl phosphinate

Refernces