methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate

Base Information

• Chemical Name: methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate
• CAS No.: 914656-00-1
• Molecular Formula: C₂₆H₂₃N₃O₅
• Molecular Weight: 457.486
• Mol file: 914656-00-1.mol

Synonyms:methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate

Chemical Property of methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate

There total 2 articles about methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-{[3-(2-methoxy-2-oxoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate (914654-35-6) → methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate (914656-00-1)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.08.085

Reference yield:

3-hydroxy-2-phenyl-4-quinolinecarboxylic acid, 2-(methoxycarbonyl)-2-phenylhydrazide (875754-99-7) → methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate (914656-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI; K₂CO₃ / tetrahydrofuran

2: LiBH₄ / tetrahydrofuran

With lithium borohydride; potassium carbonate; sodium iodide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.08.085

Reference yield:

methyl 2-{[3-(2-hydroxyethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate (914656-00-1) → Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate (914656-05-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane;

DOI:10.1016/j.bmcl.2006.08.085

upstream raw materials:

methyl 2-{[3-(2-methoxy-2-oxoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate

3-hydroxy-2-phenyl-4-quinolinecarboxylic acid, 2-(methoxycarbonyl)-2-phenylhydrazide

Downstream raw materials:

Methyl 2-{[3-(2-Bromoethoxy)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate