C₃₇H₄₀N₄O₁₀S

Base Information

Chemical Name:C₃₇H₄₀N₄O₁₀S
CAS No.:442663-62-9
Molecular Formula:C₃₇H₄₀N₄O₁₀S
Molecular Weight:732.811
Hs Code.:

C<sub>37</sub>H<sub>40</sub>N<sub>4</sub>O<sub>10</sub>S

Synonyms:C₃₇H₄₀N₄O₁₀S

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Chemical Property of C₃₇H₄₀N₄O₁₀S

Chemical Property:

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Technology Process of C₃₇H₄₀N₄O₁₀S

There total 1 articles about C₃₇H₄₀N₄O₁₀S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 442663-47-0
alcohol

: 442663-62-9
C₃₇H₄₀N₄O₁₀S

Guidance literature:: Multi-step reaction with 31 steps

1: 93 percent / pyridine; DMAP / 30 h / 50 °C

2: TFA; anisole / CH₂Cl₂ / 9 h / 20 °C

3: 19.7 g / ethyl acetate / 1 h / Heating

4: 91 percent / TEA / CH₂Cl₂ / 1 h / 0 °C

5: 97 percent / DMAP / acetonitrile / 6.5 h / 20 °C

6: NaBH₄; H₂SO₄ / ethanol; CH₂Cl₂ / 0 °C

7: 3.54 g / CSA; quinoline / toluene / 3 h / Heating

8: 83 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(o-tolyl)phosphine; TEA / acetonitrile / 2 h / Heating

9: aq. NaOH / methanol / 2.5 h / Heating

10: 106 mg / pyridine; DMAP / CH₂Cl₂ / 20 °C

11: TFA / CH₂Cl₂ / 4 h / 20 °C

12: 2.08 g / NaHCO₃ / CH₂Cl₂; H₂O / 0.17 h / 0 °C

13: dimethyldioxirane / methanol; acetone / 2 h / 0 °C

14: 652 mg / CSA / acetone / 0 - 20 °C

15: 94 percent / sodium cyanoborohydride; TFA / tetrahydrofuran / 0.5 h / 0 °C

16: 92 percent / imidazole / dimethylformamide / 2 h / 20 °C

17: 85 percent / guanidinium nitrate; NaOMe / methanol; CH₂Cl₂ / 2.5 h / 40 °C

18: 91 percent / K₂CO₃ / acetonitrile / 1 h / Heating

19: 82 percent / Red-Al / tetrahydrofuran; toluene / 0 °C

20: 73 percent / BF₃*OEt₂ / CH₂Cl₂ / 0 °C

21: 92 percent / pyridine; DMAP / 20 °C

22: 100 percent / aq. HF / acetonitrile / 3 h / 20 °C

23: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.67 h / 20 °C

24: 84 percent / H₂ / Pd/C / tetrahydrofuran / 18 h / 20 °C / 760.05 Torr

25: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 3 h / Heating

26: 99 percent / K₂CO₃ / methanol / 0.5 h / 20 °C

27: 94 percent / WSCD*HCl; DMAP / CH₂Cl₂ / 0.17 h / 20 °C

28: 98 percent / hydrazine / acetonitrile / 1.33 h / 20 °C

29: TFA / 2,2,2-trifluoro-ethanol / 3 h / 20 °C

30: 18.0 mg / pyridine; DMAP / 0.5 h / 20 °C

31: 92 percent / Zn; AcOH / diethyl ether / 2.5 h / 20 °C

With pyridine; 1H-imidazole; quinoline; dmap; sodium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; guanidinium nitrate; WSCD*HCl; TEA; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; hydrogen fluoride; hydrogen; sodium methylate; 3,3-dimethyldioxirane; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; acetic acid; methoxybenzene; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; tris-(o-tolyl)phosphine; trifluoroacetic acid; hydrazine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 8: Heck reaction;
DOI:10.1021/ja026216d

Reference yield:

: 442663-62-9
C₃₇H₄₀N₄O₁₀S

: 114899-77-3
ecteinascidin 743

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / AcOH; sodium cyanoborohydride / methanol / 1 h / 20 °C

2.1: 89 percent / Pd(PPh₃)2Cl₂; AcOH; n-Bu₃SnH / CH₂Cl₂ / 0.33 h / 20 °C

3.1: 4-formyl-1-methylpyridinium benzenesulfonate / dimethylformamide; CH₂Cl₂ / 0.25 h / 20 °C

3.2: DBU / dimethylformamide; CH₂Cl₂ / 0.42 h / 20 °C

3.3: 54 percent / aq. citric acid / CH₂Cl₂; dimethylformamide / 0.67 h / 20 °C

4.1: 96 percent / sodium acetate / ethanol / 5.5 h / 20 °C

5.1: 93 percent / silver nitrate / acetonitrile; H₂O / 17 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; sodium acetate; sodium cyanoborohydride; silver nitrate; acetic acid; N-methylpyridinium-4-carboxaldehyde benzenesulfonate salt; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja026216d

Reference yield:

: 442663-62-9
C₃₇H₄₀N₄O₁₀S

: 114899-80-8
(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / AcOH; sodium cyanoborohydride / methanol / 1 h / 20 °C

2.1: 89 percent / Pd(PPh₃)2Cl₂; AcOH; n-Bu₃SnH / CH₂Cl₂ / 0.33 h / 20 °C

3.1: 4-formyl-1-methylpyridinium benzenesulfonate / dimethylformamide; CH₂Cl₂ / 0.25 h / 20 °C

3.2: DBU / dimethylformamide; CH₂Cl₂ / 0.42 h / 20 °C

3.3: 54 percent / aq. citric acid / CH₂Cl₂; dimethylformamide / 0.67 h / 20 °C

4.1: 96 percent / sodium acetate / ethanol / 5.5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride; sodium acetate; sodium cyanoborohydride; acetic acid; N-methylpyridinium-4-carboxaldehyde benzenesulfonate salt; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja026216d