442663-47-0

Upstream product

• 533-31-3 Sesamol 
• 100-39-0 benzyl bromide 
• 442663-23-2 Trifluoro-methanesulfonic acid 7-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester 
• 244229-56-9 5-bromo-2-methoxy-3-methyl-phenol 
• 488-17-5 3-methylbenzene-1,2-diol 
• 10349-38-9 p-methoxyphenylisonitrile 
• 442663-29-8 (2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 442663-43-6 (R)-1-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamino]-2-methyl-1-phenyl-propan-2-ol 
• 442663-42-5 Trifluoro-methanesulfonic acid 7-[(R)-2-hydroxy-1-((R)-2-hydroxy-2-methyl-1-phenyl-propylamino)-ethyl]-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester 
• 442663-41-4 Trifluoro-methanesulfonic acid 7-((3R,5R)-6,6-dimethyl-2-oxo-5-phenyl-morpholin-3-yl)-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester 
• 442663-24-3 2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamine 
• 442663-28-7 3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-propionic acid 
• 442663-26-5 3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-acrylic acid methyl ester 
• 442663-27-6 3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 

Downstream Products

• 442663-48-1 Acetic acid (R)-2-{[(S)-3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-propionyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-amino}-2-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl ester 
• 308359-33-3 C₃₁H₃₁N₃O₉S 
• 442663-39-0 C₄₀H₄₃Cl₃N₄O₁₃S 
• 442663-40-3 C₄₀H₄₁Cl₃N₄O₁₂S 
• 442663-61-8 C₃₈H₄₁Cl₃N₄O₁₂S 
• 442663-57-2 C₅₀H₅₈Cl₃N₃O₁₀Si 
• 442663-56-1 nitrile compound 
• 442663-55-0 3-benzyloxy-11-[1-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-4-yl)-2-hydroxy-ethyl]-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-5-methyl-10-oxo-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2,4,6-triene-13-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 442663-53-8 silanylether 
• 442663-35-6 (3R,5R,6R,12S,12aS)-2,2,2-trichloroethyl 7-(benzyloxy)-3-[6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl]-5-{[(tert-butyldimethylsilyl)oxy]methyl}-8-methoxy-9-methyl-3,5,6,11,12,12a-hexahydro-2H-6,12-epiminobenzo[e]oxazolo[3,2-a]azocine-13-carboxylate 
• 442663-58-3 alcohol compound 
• 442663-62-9 C₃₇H₄₀N₄O₁₀S 
• 442663-36-7 (1R,9S,10R,12R)-11-[(R)-2-Acetoxy-1-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-3-benzyloxy-10-cyano-12-formyl-4-methoxy-5-methyl-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2,4,6-triene-13-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 442663-63-0 C₃₈H₄₂N₄O₁₀S 

Relevant academic research and scientific papers

PROCESS FOR TOTAL SYNTHESIS OF ECTEINASCIDINS AND INTERMEDIATES THEREFOR

An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various substituents can be introduced by mild condition, further having 10 members ring structure which can be converted to a ring of other numbered members.

Total synthesis of ecteinascidin 743

The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. Copyright