2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Base Information

• Chemical Name: 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
• CAS No.: 94066-12-3
• Molecular Formula: C₁₆H₁₃N₃O₂
• Molecular Weight: 279.298
• Mol file: 94066-12-3.mol

Synonyms:2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property of 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

There total 3 articles about 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

potassium cyanide + 2-(4-nitrophenyl)-3,4-dihydroisoquinolin-2-ium bromide (41852-30-6) → 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (94066-12-3)

Guidance literature:

In ethanol; for 0.5h;

DOI:10.3390/molecules19068051

Reference yield: 67.0%

2,2'-azobis(isobutyronitrile) (78-67-1) + 2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline (93733-03-0) → 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (94066-12-3)

Guidance literature:

With tetrabutylammomium bromide; In acetonitrile; at 20 ℃; for 3h; Electrochemical reaction; Green chemistry;

DOI:10.1039/d1ob01416a

Reference yield: 52.0%

trimethylsilyl cyanide (7677-24-9) + 2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline (93733-03-0) → 2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (94066-12-3)

Guidance literature:

With tert.-butylhydroperoxide; thiourea; In methanol; decane; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2018.12.050

upstream raw materials:

2-(4-nitrophenyl)-3,4-dihydroisoquinolin-2-ium bromide

trimethylsilyl cyanide

2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

2,2'-azobis(isobutyronitrile)