Isoquinoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-

Base Information

• Chemical Name: Isoquinoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-
• CAS No.: 93733-03-0
• Molecular Formula: C15H14N2O2
• Molecular Weight: 254.288
• Mol file: 93733-03-0.mol

Synonyms:

Chemical Property of Isoquinoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)-

There total 11 articles about Isoquinoline, 1,2,3,4-tetrahydro-2-(4-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] (905718-45-8) + 1,2,3,4-tetrahydroisoquinoline (91-21-4) → 2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline (93733-03-0)

Guidance literature:

[(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate]; With sodium carbonate; Inert atmosphere; Sealed tube;

1,2,3,4-tetrahydroisoquinoline; In toluene; at 110 ℃; for 4h; regiospecific reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201807001

Reference yield: 87.0%

1,2,3,4-tetrahydroisoquinoline (91-21-4) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline (93733-03-0)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol5018883

Reference yield: 67.0%

p-nitrobenzene iodide (636-98-6) + 1,2,3,4-tetrahydroisoquinoline (91-21-4) → 4,4'-dinitrobiphenyl (1528-74-1) + 2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline (93733-03-0)

Guidance literature:

With potassium tert-butylate; palladium diacetate; CyJohnPhos; In tert-butyl alcohol; at 100 ℃; for 0.0833333h; Microwave irradiation; Inert atmosphere;

DOI:10.1071/CH15490

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

4-chlorobenzonitrile

isochromane

1-(2-iodoethyl)-2-(iodomethyl)benzene

Downstream raw materials:

2-(4-nitrophenyl)-3,4-dihydroisoquinolin-1(2H)-one

1-(nitromethyl)-2-(4′-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

2-(4-nitrophenyl)-3,4-dihydroisoquinolin-2-ium bromide

N-(4-nitrophenyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline