(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

Base Information

Chemical Name:(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone
CAS No.:155399-25-0
Molecular Formula:C₂₃H₂₉NO₄Si
Molecular Weight:411.573
Hs Code.:

Synonyms:(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

Chemical Property:

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Technology Process of (3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

There total 1 articles about (3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132127-30-1
(3R,4S)-3-<(tert-butyldimethylsilyl)oxy>-4-phenylazetidin-2-one

: 501-53-1,94274-21-2
benzyl chloroformate

: 155399-25-0
(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 2.) THF, hexane, -78 deg C, 10 min;

Reference yield:

: 155399-25-0
(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

: 133524-70-6
13-(O-2R-hydroxy-3S-amine-phenylpropionyl)-baccatin III

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, 35 deg C, 1 h

2: 92 percent / C₅H₅N*HF / pyridine / 1.) 0 deg C, 1 h, 2.) RT, 5 h

3: 94 percent / H₂ / 10percent Pd/C / methanol / 5 h / 2585.7 Torr

With hydrogen; sodium hydride; pyridine hydrogenfluoride; palladium on activated charcoal; In pyridine; methanol;

Reference yield:

: 155399-25-0
(3R,4S)-1-(benzyloxycarbonyl)-3-<(tert-butyldimethylsilyl)oxy>-4-phenyl-2-azetidinone

: 153695-19-3
N-(4-azidobenzoyl)-N-debenzoyltaxol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, 35 deg C, 1 h

2: 92 percent / C₅H₅N*HF / pyridine / 1.) 0 deg C, 1 h, 2.) RT, 5 h

3: 94 percent / H₂ / 10percent Pd/C / methanol / 5 h / 2585.7 Torr

4: 72 percent / aq. NaHCO₃ / ethyl acetate / 0.08 h

With hydrogen; sodium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; palladium on activated charcoal; In pyridine; methanol; ethyl acetate;