methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

Base Information

Chemical Name:methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate
CAS No.:1446282-69-4
Molecular Formula:C₁₆H₁₂F₅NO₅S
Molecular Weight:425.333
Hs Code.:

Synonyms:methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

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Technology Process of methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

There total 3 articles about methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 832-53-1
pentafluorobenzenesulonyl chloride

: 192313-50-1
(S)-2-amino-2-(4-methoxy-phenyl)acetic acid methyl ester

: 1446282-69-4
methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 16h;
DOI:10.1021/ol401557v

Reference yield:

: 69651-48-5
N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

: 1446282-69-4
methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / methanol; diethyl ether / 4 h / 0 - 20 °C

2: chloroform / 4 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 25 °C

With aluminum (III) chloride; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; chloroform;
DOI:10.1021/ol401557v

Reference yield:

: 183671-61-6
(S)-tert-butoxycarbonylamino(4-methoxyphenyl)acetic acid methyl ester

: 1446282-69-4
methyl (S)-2-(4-methoxyphenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: chloroform / 4 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 25 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;
DOI:10.1021/ol401557v