69651-48-5

Basic information

• Product Name: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid
• Synonyms: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid;(2S)-2-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid;(S)-2-((tert-Butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetic acid;N-Boc-S-4-Hydroxyphenylglycine
• CAS NO: 69651-48-5
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.27778
• Mol File: 69651-48-5.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid(69651-48-5)
• EPA Substance Registry System: Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid(69651-48-5)

Safety Data

• Hazardous Substances Data: 69651-48-5(Hazardous Substances Data)

Usage

General Description

Boc-(S)-2-amino-2-(4-hydroxyphenyl)acetic acid is a chemical compound containing an amino acid derivative and a Boc-protecting group. It is commonly used in the synthesis of peptides and pharmaceuticals. The "Boc" in its name refers to the tert-butoxycarbonyl group, which is a common protecting group in organic synthesis. The presence of the 4-hydroxyphenyl group makes this compound potentially useful in the development of drugs targeting conditions such as Alzheimer's disease and cancer. The (S) in its name denotes the stereochemistry of the molecule, indicating the presence of a chiral center. Overall, this chemical compound has versatile uses in organic synthesis and pharmaceutical research.

Upstream product

• 32462-30-9 (S)-hydroxyphenylglycine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22818-40-2 D-4-hydroxyphenylglycine 

Downstream Products

• 112896-90-9 N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(S)-4-hydroxyphenylglycine 
• 209796-46-3 (S)-tert-butoxycarbonylamino-(cis-4-hydroxy-cyclohexyl)-acetic acid 
• 1073560-70-9 C₂₆H₂₉N₅O₅S 
• 1149741-34-3 C₄₇H₅₁N₃O₉ 
• 1338925-48-6 Boc-N-Me-3-Iodo-hydroxyphenylglycine 
• 1443793-08-5 N-(tert-butyloxycarbonyl)-L-(p-hydroxyphenyl)glycine-L-arginine-(Pbf) benzyl ester 

Relevant articles and documents

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Synthesis method of hydroxylamine imidazole cephalosporin propylene glycol drug intermediate D-alpha-tert-butoxy carbonyl amino-alpha-(4-hydroxyphenyl)-acetic acid

The invention provides a synthesis method of a hydroxylamine imidazole cephalosporin propylene glycol drug intermediate D-alpha-tert-butoxy carbonyl amino-alpha-(4-hydroxyphenyl)-acetic acid. The method comprises the following steps that (i), 200 ml of a propionitrile solution, 0.06 mol of D-(-)-hydroxy phenylglycine and 0.08 mol of sodium bromide are added into a reactor provided with a stirrer, a condensation backflow device and a thermometer, stirring speed is controlled to range from 160 rpm to 190 rpm, stirring time is controlled to range from 90 min to 120 min, 0.081-0.085 mol of tert-butoxycarbonylation bromine is added slowly in batches, solution temperature is controlled to range from 60 DEG C to 65 DEG C, reaction time ranges from 19 h to 20 h, 500 ml of a potassium bromide solution is added for dilution, ethidene diamine is used for carrying out extraction 6-8 times, extract is dehydrated with calcium chloride, pressure reduction distillation is carried out to steam solvent out, residues are added into a butanol solution, a solid is smashed and filtered to obtain D-alpha-tert-butoxy carbonyl amino-alpha-(4-hydroxyphenyl)-acetic acid. The mass fraction of the propionitrile solution in the step (i) is 55-65%, and the mass fraction of the potassium bromide solution in the step (i) is 35-40%.