N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide

Base Information

• Chemical Name: N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide
• CAS No.: 438553-51-6
• Molecular Formula: C₁₂H₁₆BrNO₃
• Molecular Weight: 302.168
• Mol file: 438553-51-6.mol

Synonyms:N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide

Chemical Property of N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide

There total 1 articles about N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-4-methoxyaniline (32338-02-6) + 3-methyltetrahydro-2-furanone (1679-47-6) → N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide (438553-51-6)

Guidance literature:

With trimethylaluminum; In toluene;

DOI:10.1016/S0040-4039(02)00059-X

Reference yield: 86.2%

acetyl chloride (75-36-5) + N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide (438553-51-6) → C14H18BrNO4

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/j.tetlet.2016.06.005

Reference yield:

N-(2-bromo-4-methoxy-phenyl)-4-hydroxy-2-methyl-butyramide (438553-51-6) → N-(2-bromo-4-methoxy-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-2,N-dimethyl-butyramide (438553-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether

2: NaH / tetrahydrofuran

With sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4039(02)00059-X

upstream raw materials:

2-bromo-4-methoxyaniline

3-methyltetrahydro-2-furanone

Downstream raw materials:

N-(2-bromo-4-methoxy-phenyl)-4-(tert-butyl-dimethyl-silanyloxy)-2,N-dimethyl-butyramide