cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone

Base Information

• Chemical Name: cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone
• CAS No.: 315674-93-2
• Molecular Formula: C₃₅H₃₂N₂O₂
• Molecular Weight: 512.651
• Mol file: 315674-93-2.mol

Synonyms:cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone

Chemical Property of cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone

There total 4 articles about cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropyl 4-hydroxyphenyl ketone (36116-18-4) + 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone (315674-93-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/S0960-894X(00)00473-X

Reference yield:

cyclopropyl(4-fluorophenyl)methanone (772-31-6) + 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone (315674-93-2)

Guidance literature:

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol; With sodium hydride; In toluene;

cyclopropyl(4-fluorophenyl)methanone; In toluene; Heating;

DOI:10.1016/S0960-894X(00)00473-X

Reference yield:

cyclopropyl(4-fluorophenyl)methanone (772-31-6) + sodium 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanolate → cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone (315674-93-2)

Guidance literature:

With sodium hydride; In toluene; Heating;

DOI:10.1002/1521-4184(20009)333:9<315::AID-ARDP315>3.0.CO;2-M

upstream raw materials:

cyclopropyl(4-fluorophenyl)methanone

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol

cyclopropyl 4-hydroxyphenyl ketone

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Downstream raw materials:

ciproxifan

FUB 360

4-Hydroxy-1-(4-(3-(1H-imidazol-4-yl)propyloxy)phenyl)butanone ethylene acetal