(1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester
• CAS No.: 75399-80-3
• Molecular Formula: C₂₃H₃₄O₂
• Molecular Weight: 342.522
• Mol file: 75399-80-3.mol

Synonyms:(1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester

Chemical Property of (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester

There total 5 articles about (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

maleopimaric acid methyl ester (54868-63-2) → (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester (75399-80-3)

Guidance literature:

With Triethylene glycol dimethyl ether; bis(triphenylphosphine)nickel⁽⁰⁾ dicarbonyl; at 220 ℃; for 22h;

DOI:10.1007/PL00000088

Reference yield: 8.0%

13-isopropyl-17,18-dinoratis-13-ene-15β,16α-dicarboxy-4-carboxylic acid methyl ester → (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester (75399-80-3)

Guidance literature:

With quinoline; [2,2]bipyridinyl; copper(I) oxide; at 200 ℃; for 7h;

DOI:10.1007/PL00000088

Reference yield:

2-[2-((1R,2R,6R)-2-Ethoxycarbonyl-2,6-dimethyl-6-vinyl-cyclohexyl)-ethyl]-4-isopropyl-benzoic acid ethyl ester (75399-78-9) → (1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid methyl ester (75399-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / methanolic KOH / 8 h / Heating

2: 35 percent / Cu₂O / quinoline / 5 h / 240 °C

3: hexamethylphosphoric acid triamide; aq. NaOH / Ambient temperature

With copper(I) oxide; potassium hydroxide; In quinoline; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide;

DOI:10.1021/jo01314a055

upstream raw materials:

(1R,2R,3R)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-3-vinyl-cyclohexanecarboxylic acid

methyl iodide

maleopimaric acid methyl ester

2-[2-((1R,2R,6R)-2-Carboxy-2,6-dimethyl-6-vinyl-cyclohexyl)-ethyl]-4-isopropyl-benzoic acid

Downstream raw materials:

(1R,2R,3S)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-cyclohexane-1,3-dicarboxylic acid monomethyl ester