3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Base Information

• Chemical Name: 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one
• CAS No.: 1172590-86-1
• Molecular Formula: C₁₇H₁₃NO₂
• Molecular Weight: 263.296
• Mol file: 1172590-86-1.mol

Synonyms:3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Chemical Property of 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one

There total 6 articles about 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-1H-indole-2,3-dione (2058-74-4) + phenylacetylene (536-74-3) → 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1172590-86-1)

Guidance literature:

With C₄₂H₆₂AgN₄⁽¹⁺⁾*BF₄^(1-); In methanol; water; at 60 ℃; for 15h;

DOI:10.1002/cctc.201500869

Reference yield: 88.0%

1-methyl-1H-indole-2,3-dione (2058-74-4) + 1-iodo-2-phenylethyne (932-88-7) → 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1172590-86-1)

Guidance literature:

With zinc; In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.tetlet.2016.11.124

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one (1172590-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201801080

upstream raw materials:

1-methyl-1H-indole-2,3-dione

phenylacetylene

1-iodo-2-phenylethyne

phenylethynylmagnesium bromide