2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

Base Information

Chemical Name:2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide
CAS No.:951238-20-3
Molecular Formula:C₂₈H₄₉N₉O₄
Molecular Weight:575.755
Hs Code.:

Synonyms:2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

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Chemical Property of 2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

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Technology Process of 2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

There total 3 articles about 2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 951238-19-0
2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

: 951238-20-3
2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

Guidance literature:: With hydrazine hydrate; palladium on activated charcoal; In ethanol; at 90 ℃;
DOI:10.1039/b705560a

Reference yield:

: 622872-56-4
2-(4,10-bis-dimethyl-carbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-N,N-dimethyl-acetamide

: 951238-20-3
2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / cesium carbonate; potassium iodide / acetonitrile / 72 h / 85 °C

2: 88 percent / hydrazine monohydrate / Pd/C / ethanol / 90 °C

With caesium carbonate; hydrazine hydrate; potassium iodide; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1039/b705560a

Reference yield:

: 1-(N-(4-nitrophenyl)carbamoylmethyl)-1,4,7,10-tetraazacyclododecane

: 951238-20-3
2-{4[(4-amino-phenylcarbamoyl)-methyl]-7,10-(bis-dimethylcarbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)}-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 126 h / 85 °C / Inert atmosphere; Cooling with acetone-dry ice

2: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 2 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; potassium carbonate; hydrazine hydrate; potassium iodide; In ethanol; acetonitrile;
DOI:10.1021/ja300887k