2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

Base Information

Chemical Name:2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide
CAS No.:951238-19-0
Molecular Formula:C₂₈H₄₇N₉O₆
Molecular Weight:605.738
Hs Code.:

Synonyms:2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

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Chemical Property of 2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

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Technology Process of 2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

There total 4 articles about 2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1-(N-(4-nitrophenyl)carbamoylmethyl)-1,4,7,10-tetraazacyclododecane

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 951238-19-0
2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 85 ℃; for 126h; Inert atmosphere; Cooling with acetone-dry ice;
DOI:10.1021/ja300887k

Reference yield: 74.0%

: 17329-87-2
2-chloro-N-(4-nitro-phenyl)-acetamide

: 622872-56-4
2-(4,10-bis-dimethyl-carbamoylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-N,N-dimethyl-acetamide

: 951238-19-0
2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

Guidance literature:: With caesium carbonate; potassium iodide; In acetonitrile; at 85 ℃; for 72h;
DOI:10.1039/b705560a

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 951238-19-0
2-{4,7-bis-dimethylcarbamoylmethyl-10-[(4-nitro-phenylcarbamoyl)-methyl]-1,4,7,10-tetraaza-cyclododec-1-yl}-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 48.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / chloroform / 20 °C

3: potassium carbonate; potassium iodide / acetonitrile / 126 h / 85 °C / Inert atmosphere; Cooling with acetone-dry ice

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; chloroform; acetonitrile;
DOI:10.1021/ja300887k