succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester

Base Information

• Chemical Name: succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester
• CAS No.: 331465-56-6
• Molecular Formula: C₇₀H₇₆N₄O₁₃Si
• Molecular Weight: 1209.48

Synonyms:succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester

Chemical Property of succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester

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Technology Process of succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester

There total 6 articles about succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

succinic acid anhydride (108-30-5) + [2,2']bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide) (331465-55-5) → succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester (331465-56-6)

Guidance literature:

With pyridine; dmap; at 20 ℃;

DOI:10.1016/S0960-894X(00)00673-9

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester (331465-56-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / 4-(dimethylamino)pyridine; pyridine / 2 h

2: 98 percent / piperidine / dimethylformamide / 3 h

3: 85 percent / pyridine / dimethylformamide / 20 °C

4: 58 percent / imidazole; pyridine / dimethylformamide / 20 °C

5: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

With piperidine; pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00673-9

Reference yield:

2-amino-1-O-(4,4'-dimethoxytrityl)propane-1,3-diol (154928-41-3) → succinic acid mono-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-({4'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-propyl] ester (331465-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / pyridine / dimethylformamide / 20 °C

2: 58 percent / imidazole; pyridine / dimethylformamide / 20 °C

3: 97 percent / 4-(dimethylamino)pyridine; pyridine / 20 °C

With pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00673-9

upstream raw materials:

succinic acid anhydride

[2,2']bipyridinyl-4,4'-dicarboxylic acid 4-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-amide} 4'-({2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-amide)

4,4'-dimethoxytrityl chloride

2-amino-1-O-(4,4'-dimethoxytrityl)propane-1,3-diol

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