benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

Base Information

Chemical Name:benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate
CAS No.:1337557-48-8
Molecular Formula:C₃₈H₆₃NO₇Si₂
Molecular Weight:702.092
Hs Code.:

Synonyms:benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

There total 6 articles about benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1233851-82-5
benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-enyl)carbamate

: 1337557-48-8
benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

Guidance literature:: benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-enyl)carbamate; With dimethylsulfide borane complex; In tetrahydrofuran; at -10 - 20 ℃; for 3h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2011.07.009

Reference yield:

: 1233851-77-8
C₂₁H₃₅NO₄Si

: 1337557-48-8
benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc / tetrahydrofuran / -15 - 20 °C

2.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 1 h / 20 °C / Cooling with ice

4.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -10 - 20 °C

4.2: 2 h / 0 - 20 °C

With 1H-imidazole; dimethylsulfide borane complex; sodium hydride; zinc; In tetrahydrofuran; dichloromethane; toluene; mineral oil;
DOI:10.1016/j.tetasy.2011.07.009

Reference yield:

: 1233851-81-4
(S)-N-benzyl-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-amine

: 1337557-48-8
benzyl benzyl((S)-1-((4S,5S)-5-((R)-3,3-diethyl-8,8,9,9-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxybutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; toluene; mineral oil / 1 h / 20 °C / Cooling with ice

2.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -10 - 20 °C

2.2: 2 h / 0 - 20 °C

With dimethylsulfide borane complex; sodium hydride; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.tetasy.2011.07.009