Technology Process of benzyl (2S)-2-[(1E)-2-nitroprop-1-en-1-yl]piperidine-1-carboxylate
There total 5 articles about benzyl (2S)-2-[(1E)-2-nitroprop-1-en-1-yl]piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.666667h;
DOI:10.1016/j.tet.2013.05.055
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Reflux
2: potassium carbonate / acetonitrile / 6 h / 0 °C
3: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / -78 °C
4: potassium hydroxide / methanol / 1 h / 20 °C
5: triethylamine; methanesulfonyl chloride / dichloromethane / 0.67 h / 0 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
3: |Swern Oxidation / 4: |Henry Nitro Aldol Condensation / 5: |Henry Nitro Aldol Condensation;
DOI:10.1016/j.tet.2013.05.055
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile / 6 h / 0 °C
2: oxalyl dichloride; triethylamine; dimethyl sulfoxide / dichloromethane / -78 °C
3: potassium hydroxide / methanol / 1 h / 20 °C
4: triethylamine; methanesulfonyl chloride / dichloromethane / 0.67 h / 0 °C
With
oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; potassium hydroxide;
In
methanol; dichloromethane; acetonitrile;
2: |Swern Oxidation / 3: |Henry Nitro Aldol Condensation / 4: |Henry Nitro Aldol Condensation;
DOI:10.1016/j.tet.2013.05.055
