Technology Process of (12-Benzyloxy-6,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1(14),11(15),12-trien-3-yl)acetic acid
There total 3 articles about (12-Benzyloxy-6,9-bis(carboxymethyl)-3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1(14),11(15),12-trien-3-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(12-benzyloxy-6,9-bis(methoxycarbonylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1(14),11(15),12-trien-3-yl)acetic acid, methyl ester of;
With
sodium hydroxide;
In
methanol; water;
for 6h;
Reflux;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 12 h / Reflux
2.1: carbon tetrabromide; triphenylphosphine / acetonitrile / 6 h / 5 - 20 °C
3.1: potassium carbonate / acetonitrile / 2 h / Reflux
4.1: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 20 °C
5.1: potassium carbonate / acetonitrile / 18 h / Reflux
6.1: sodium hydroxide / water; methanol / 6 h / Reflux
6.2: IRC50 resin
With
carbon tetrabromide; potassium carbonate; mercaptoacetic acid; triphenylphosphine; sodium hydroxide; lithium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 20 - 90 °C
2.1: potassium carbonate / acetonitrile / 12 h / Reflux
3.1: carbon tetrabromide; triphenylphosphine / acetonitrile / 6 h / 5 - 20 °C
4.1: potassium carbonate / acetonitrile / 2 h / Reflux
5.1: mercaptoacetic acid; lithium hydroxide / N,N-dimethyl-formamide / 20 °C
6.1: potassium carbonate / acetonitrile / 18 h / Reflux
7.1: sodium hydroxide / water; methanol / 6 h / Reflux
7.2: IRC50 resin
With
carbon tetrabromide; potassium carbonate; mercaptoacetic acid; triphenylphosphine; sodium hydroxide; lithium hydroxide;
In
methanol; water; N,N-dimethyl-formamide; acetonitrile;
![(12-benzyloxy-6,9-bis(methoxycarbonylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]-pentadeca-1<sup>(14)</sup>,11<sup>(15)</sup>,12-trien-3-yl)acetic acid, methyl ester of](/Databaselist/images/loading.webp)
