(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

Base Information

Chemical Name:(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide
CAS No.:1351186-29-2
Molecular Formula:C₃₀H₄₇NO₂Si
Molecular Weight:481.794
Hs Code.:

Synonyms:(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

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Chemical Property of (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

Chemical Property:

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Technology Process of (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

There total 8 articles about (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1351186-20-3
(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide

: 74-88-4
methyl iodide

: 1351186-29-2
(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo201951s

Reference yield:

: C₂₅H₃₈O₄SSi

: 1351186-29-2
(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 - 40 °C

2: water; triphenylphosphine / tetrahydrofuran / 12 h / 20 - 40 °C

3: diethyl cyanophosphonate; triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

4: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; diethyl cyanophosphonate; water; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 2: Staudinger reaction;
DOI:10.1021/jo201951s

Reference yield:

: 1351186-26-9
((2R,4S)-6-azido-2,4-dimethylhexyloxy)(tert-butyl)diphenylsilane

: 1351186-29-2
(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; triphenylphosphine / tetrahydrofuran / 12 h / 20 - 40 °C

2: diethyl cyanophosphonate; triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

3: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; diethyl cyanophosphonate; water; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 1: Staudinger reaction;
DOI:10.1021/jo201951s