benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Base Information

Chemical Name:benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate
CAS No.:1280666-80-9
Molecular Formula:C₂₄H₂₁NO₈S
Molecular Weight:483.499
Hs Code.:

Synonyms:benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Chemical Property of benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

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Technology Process of benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

There total 6 articles about benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 1280666-79-6
benzyl 2-(hydroxymethyl)-7-nitro-2,3-dihydrobenzofuran-4-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1280666-80-9
benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 - 30 ℃; for 2h; Cooling with ice; Inert atmosphere;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1280666-80-9
benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Inert atmosphere

2: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3: 3.5 h / 190 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere

5: triethylamine / dichloromethane / 2 h / 20 - 30 °C / Cooling with ice; Inert atmosphere

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid; In dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1280666-80-9
benzyl 7-nitro-2-(toluen-4-sulfonyloxymethyl)-2,3-dihydrobenzofuran-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Inert atmosphere

2: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3: 3.5 h / 190 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere

5: triethylamine / dichloromethane / 2 h / 20 - 30 °C / Cooling with ice; Inert atmosphere

With potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid; In dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;