2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

Base Information

Chemical Name:2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide
CAS No.:1544674-08-9
Molecular Formula:C₂₉H₃₂N₂O₂
Molecular Weight:440.585
Hs Code.:

Synonyms:2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

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Chemical Property of 2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

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Technology Process of 2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

There total 7 articles about 2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 108-86-1,52753-63-6
bromobenzene

: 1544673-86-0
N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

: 1544674-08-9
2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

Guidance literature:: With bis(triphenylphosphine)palladium(II) chloride; triethylamine; In ethanol; for 10h; Reflux; Inert atmosphere;
DOI:10.3390/molecules181012346

Reference yield:

: 269410-09-5
(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine

: 1544674-08-9
2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 2 h / 50 °C / Microwave irradiation

1.2: 2 h / 50 °C / Microwave irradiation

2.1: bis(triphenylphosphine)palladium(II) chloride; triethylamine / ethanol / 10 h / Reflux; Inert atmosphere

With bis(triphenylphosphine)palladium(II) chloride; triethylamine; In methanol; ethanol; 2.1: |Suzuki Coupling;
DOI:10.3390/molecules181012346

Reference yield:

: 443776-76-9
(3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol

: 1544674-08-9
2-[N-([1,1'-biphenyl]-3-ylmethyl)acetamido]-N-cyclohexyl-2-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: hydrazine hydrate / tetrahydrofuran / 12 h / Reflux

4.1: methanol / 2 h / 50 °C / Microwave irradiation

4.2: 2 h / 50 °C / Microwave irradiation

5.1: bis(triphenylphosphine)palladium(II) chloride; triethylamine / ethanol / 10 h / Reflux; Inert atmosphere

With bis(triphenylphosphine)palladium(II) chloride; potassium carbonate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 5.1: |Suzuki Coupling;
DOI:10.3390/molecules181012346