N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

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Chemical Name:N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide
CAS No.:1544673-86-0
Molecular Formula:C₂₉H₃₉BN₂O₄
Molecular Weight:490.451
Hs Code.:

Synonyms:N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

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Chemical Property of N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

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Technology Process of N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

There total 7 articles about N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 269410-09-5
(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine

: 931-53-3
Cyclohexyl isocyanide

: 100-52-7
benzaldehyde

: 64-19-7,77671-22-8
acetic acid

: 1544673-86-0
N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

Guidance literature:: (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine; benzaldehyde; In methanol; at 50 ℃; for 2h; Microwave irradiation;

Cyclohexyl isocyanide; acetic acid; at 50 ℃; for 2h; Microwave irradiation;
DOI:10.3390/molecules181012346

Reference yield:

: 87199-16-4
3-Formylphenylboronic acid

: 1544673-86-0
N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium sulfate / methanol / 6 h / 20 °C

2.1: sodium tetrahydroborate / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: hydrazine hydrate / tetrahydrofuran / 12 h / Reflux

6.1: methanol / 2 h / 50 °C / Microwave irradiation

6.2: 2 h / 50 °C / Microwave irradiation

With sodium tetrahydroborate; magnesium sulfate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules181012346

Reference yield:

: 443776-76-9
(3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol

: 1544673-86-0
N-cyclohexyl-2-phenyl-2-{N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: hydrazine hydrate / tetrahydrofuran / 12 h / Reflux

4.1: methanol / 2 h / 50 °C / Microwave irradiation

4.2: 2 h / 50 °C / Microwave irradiation

With potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules181012346