D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Base Information

Chemical Name:D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester
CAS No.:1429301-63-2
Molecular Formula:C₃₇H₄₆N₄O₉
Molecular Weight:690.794
Hs Code.:

Synonyms:D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Suppliers and Price of D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

There total 6 articles about D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1429301-62-1
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

: 63983-89-1
D-alanyl-D-alanine benzyl ester

: 1429301-63-2
D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

D-alanyl-D-alanine benzyl ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/bi400211q

Reference yield:

: 1429301-61-0
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid ethyl ester

: 1429301-63-2
D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 5 - 10 °C

2: 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/bi400211q

Reference yield:

: 1429301-58-5
D-6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)-trans-hex-2-enoic acid ethyl ester

: 1429301-63-2
D-6-benzyloxycarbonylamino-6-[N-(2',4'-dimethoxybenzyl)carbamoyl]hexanoyl-D-alanyl-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / 2585.81 Torr

2.1: sodium carbonate / water; 1,4-dioxane / 20 °C

3.1: HATU / N,N-dimethyl-formamide / Inert atmosphere

3.2: 20 °C / Inert atmosphere; Cooling

4.1: lithium hydroxide / tetrahydrofuran; water / 5 - 10 °C

5.1: 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/bi400211q