D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

Base Information

Chemical Name:D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid
CAS No.:1429301-62-1
Molecular Formula:C₂₄H₃₀N₂O₇
Molecular Weight:458.511
Hs Code.:

Synonyms:D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

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Chemical Property of D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

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Technology Process of D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

There total 5 articles about D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1429301-61-0
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid ethyl ester

: 1429301-62-1
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 5 - 10 ℃;
DOI:10.1021/bi400211q

Reference yield:

: 1429301-58-5
D-6-(N,N-dibenzylamino)-6-(benzyloxycarbonyl)-trans-hex-2-enoic acid ethyl ester

: 1429301-62-1
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / 2585.81 Torr

2.1: sodium carbonate / water; 1,4-dioxane / 20 °C

3.1: HATU / N,N-dimethyl-formamide / Inert atmosphere

3.2: 20 °C / Inert atmosphere; Cooling

4.1: lithium hydroxide / tetrahydrofuran; water / 5 - 10 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/bi400211q

Reference yield:

: 1237770-00-1
D-4-(N,N-dibenzylamino)-4-(benzyloxycarbonyl)butanal

: 1429301-62-1
D-6-benzyloxycarbonylamino-6-[N-(2′,4′-dimethoxybenzyl)carbamoyl]hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / 2585.81 Torr

3.1: sodium carbonate / water; 1,4-dioxane / 20 °C

4.1: HATU / N,N-dimethyl-formamide / Inert atmosphere

4.2: 20 °C / Inert atmosphere; Cooling

5.1: lithium hydroxide / tetrahydrofuran; water / 5 - 10 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/bi400211q