cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)

Base Information

• Chemical Name: cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)
• CAS No.: 172587-61-0
• Molecular Formula: C₁₄H₁₅Cl₂N₃O₅S
• Molecular Weight: 408.262
• Mol file: 172587-61-0.mol

Synonyms:cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)

Chemical Property of cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)

There total 8 articles about cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanesulfonyl chloride (124-63-0) + (-)-(2S,cis)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol (172587-60-9) → cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester) (172587-61-0,854372-78-4)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 16h;

DOI:10.1016/0957-4166(95)00313-E

Reference yield:

cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane (170210-46-5) → cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester) (172587-61-0,854372-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMSO, RT, 1 h, 2.) DMSO, 130 deg C, 16 h

2: aq. NaOH / dioxane / 2 h / Heating

3: 93 percent / pyridine / 16 h / 0 - 20 °C

With pyridine; sodium hydroxide; sodium hydride; In 1,4-dioxane;

DOI:10.1016/0957-4166(95)00313-E

Reference yield:

cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol benzoate (ester) (67914-84-5) → cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester) (172587-61-0,854372-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / dioxane / 2 h / Heating

2: 93 percent / pyridine / 16 h / 0 - 20 °C

With pyridine; sodium hydroxide; In 1,4-dioxane;

DOI:10.1016/0957-4166(95)00313-E

upstream raw materials:

methanesulfonyl chloride

(-)-(2S,cis)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol

cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane

cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol benzoate (ester)

Downstream raw materials:

(-)-terconazole

2S,4R,2'S,3'S hydroxy itraconazole