cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane

Base Information

• Chemical Name: cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane
• CAS No.: 170210-46-5
• Molecular Formula: C₁₈H₁₅BrCl₂O₄
• Molecular Weight: 446.125
• Mol file: 170210-46-5.mol

Synonyms:cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane

Chemical Property of cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane

There total 6 articles about cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H15BrCl2O4 → cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane (170210-46-5)

Guidance literature:

C₁₈H₁₅BrCl₂O₄; In methanol; at 25 ℃; for 1h;

With tert-butyl methyl ether; In methanol; at 60 ℃; for 0.5h;

Reference yield:

2,4-dichlorophenacyl bromide (2631-72-3) → cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane (170210-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH*H₂O / toluene; butan-1-ol / 24 h / Heating

2: dimethylformamide / 6 h / 160 - 165 °C

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; butan-1-ol;

DOI:10.1016/0957-4166(95)00161-H

Reference yield:

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → cis-2-bromomethyl-2-(2,4-dichlorophenyl)-4-phenylcarbonyloxymethyl-1,3-dioxolane (170210-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 - 25 °C

1.2: 5 h / 90 °C

2.1: toluene-4-sulfonic acid / toluene; butan-1-ol / 36 h / 130 °C

3.1: N,N-dimethyl-formamide / 5 h / 160 - 165 °C

4.1: methanol / 1 h / 25 °C

4.2: 0.5 h / 60 °C

With N-Bromosuccinimide; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;

upstream raw materials:

sodium benzoate

2,4-dichlorophenacyl bromide

1-(2,4-dichlorophenyl)ethan-1-one

Downstream raw materials:

2S,4R,2'S,3'S hydroxy itraconazole

(-)-(2S,cis)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol

(-)-terconazole

cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate (ester)