(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

Base Information

Chemical Name:(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid
CAS No.:1357485-74-5
Molecular Formula:C₄₅H₅₆N₂O₉Si
Molecular Weight:797.033
Hs Code.:

(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

Synonyms:(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

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Chemical Property of (2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

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Technology Process of (2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

There total 5 articles about (2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1357485-73-4
(2S,3S)-1-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyl) 4-benzyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tertbutyldimethylsilyloxy)succinate

: 1357485-74-5
(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 0.833333h; under 760.051 Torr;
DOI:10.1007/s00726-010-0806-x

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1357485-74-5
(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; acetone / 2 h

2: dmap; diisopropyl-carbodiimide / dichloromethane

3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 0.83 h / 20 °C / 760.05 Torr

With dmap; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; diisopropyl-carbodiimide; In dichloromethane; water; ethyl acetate; acetone;
DOI:10.1007/s00726-010-0806-x

Reference yield:

: 1357485-71-2
(2S,3S)-2-amino-4-(benzyloxy)-3-(tertbutyldimethylsilyloxy)-4-oxobutanoic acid

: 1357485-74-5
(2S,3S)-4-(4-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)benzyloxy)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2-(tert-butyldimethylsilyloxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; acetone / 2 h

2: dmap; diisopropyl-carbodiimide / dichloromethane

3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 0.83 h / 20 °C / 760.05 Torr

With dmap; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; diisopropyl-carbodiimide; In dichloromethane; water; ethyl acetate; acetone;
DOI:10.1007/s00726-010-0806-x