Technology Process of (2R,3R)-1,2-O-cyclohexylidene-3-O-benzyl-tridecane-1,2,3-triol
There total 1 articles about (2R,3R)-1,2-O-cyclohexylidene-3-O-benzyl-tridecane-1,2,3-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3R)-1,2-cyclohexylidenetridecane-1,2,3-triol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 60 ℃;
for 1h;
Inert atmosphere;
benzyl bromide;
In
tetrahydrofuran; mineral oil;
at 20 - 60 ℃;
for 3h;
Inert atmosphere;
DOI:10.1016/j.tetasy.2011.08.013
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / dichloromethane; water / 2.5 h / 0 °C
2.1: pyridine; dmap / 2 h / 0 °C
3.1: potassium carbonate / methanol / 3 h / 20 °C
4.1: magnesium / tetrahydrofuran
4.2: 0.25 h / -50 °C
5.1: 1H-imidazole / dichloromethane / 10 h / 20 °C
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C
7.1: pyridine; dmap / 6 h / 0 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere
With
pyridine; 1H-imidazole; dmap; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; magnesium; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.tetasy.2011.08.013
