4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

Base Information

Chemical Name:4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt
CAS No.:955360-43-7
Molecular Formula:C₂₀H₂₀ClN₃O*ClH
Molecular Weight:390.312
Hs Code.:

Synonyms:4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

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Chemical Property of 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

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Technology Process of 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

There total 7 articles about 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 53242-88-9
4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

: 132482-10-1
(R)-1-<(1,1-dimethylethoxy)carbonyl>-2-pyrrolidinemethanolmethanesulfonate

: 955360-43-7
4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

Guidance literature:: 4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone; (R)-1-<(1,1-dimethylethoxy)carbonyl>-2-pyrrolidinemethanolmethanesulfonate; With caesium carbonate; In 4-methyl-2-pentanone; at 100 ℃; for 19h;

With hydrogenchloride; isopropyl alcohol; at 22 ℃; for 15h;

Reference yield:

: 955359-78-1
1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate

: 955360-43-7
4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 4h; Cooling with ice;
DOI:10.1021/jm1013874

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 955360-43-7
4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / 1-methyl-pyrrolidin-2-one / 48 h / 200 °C

2.1: hydrazine / ethanol / 15 h / 85 °C

2.2: 2 h / 2 °C

3.1: caesium carbonate / 4-methyl-2-pentanone / 19 h / 100 °C

3.2: 15 h / 22 °C

With sodium acetate; caesium carbonate; hydrazine; In 1-methyl-pyrrolidin-2-one; ethanol; 4-methyl-2-pentanone;