1-O-Hexadecyl-2-O-methyl-rac-glycerol

Base Information

• Chemical Name: 1-O-Hexadecyl-2-O-methyl-rac-glycerol
• CAS No.: 84337-41-7
• Molecular Formula: C20H42 O3
• Molecular Weight: 330.55
• Mol file: 84337-41-7.mol

Synonyms:3-Hexadecyloxy-2-methoxypropanol

Chemical Property of 1-O-Hexadecyl-2-O-methyl-rac-glycerol

Chemical Property:

• Boiling Point: 430.6±25.0 °C(Predicted)
• PKA: 14.20±0.10(Predicted)
• PSA: 38.69000
• Density: 0.895±0.06 g/cm3(Predicted)
• LogP: 5.49160

Purity/Quality:

97% ^*data from raw suppliers

1-O-Hexadecyl-2-O-methylglycerol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-O-Hexadecyl-2-O-methyl-rac-glycerol

There total 10 articles about 1-O-Hexadecyl-2-O-methyl-rac-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-O-benzyl-2-O-methyl-3-O-hexadecyl-rac-glycerol (138329-15-4) → 3-(hexadecyloxy)-2-methoxy-1-propanol (84337-41-7,111188-59-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃;

DOI:10.1007/BF00766461

Reference yield: 46.0%

2-methylglycerol (761-06-8) + 1-iodohexadecane (544-77-4) → 3-(hexadecyloxy)-2-methoxy-1-propanol (84337-41-7,111188-59-1)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield: 45.0%

2-methylglycerol (761-06-8) + hexadecanyl bromide (112-82-3) → 3-(hexadecyloxy)-2-methoxy-1-propanol (84337-41-7,111188-59-1)

Guidance literature:

In toluene;

upstream raw materials:

1-O-benzyl-2-O-methyl-3-O-hexadecyl-rac-glycerol

2-methylglycerol

hexadecanyl bromide

3-(hexadecyloxy)-1,2-propanediol

Downstream raw materials:

3-(Hexadecyloxy)-2-methoxypropyl phenyl phosphorochloridate

Refernces

• 1、 Pinchuk,Mitsner,Shvets. "Synthesis of alkyl glycerophospholipids through 1-o-benzyl-2-o-methyl-rac-glycerol". . p. 174 - 176. Retrieved 2007/10/02.
• 2、 -. "Phospholipid analogs useful as PAF synthesis inhibitors". . . Retrieved 2008/06/13.