3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

Base Information

Chemical Name:3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester
CAS No.:1343454-99-8
Molecular Formula:C₂₅H₃₃N₃O₃
Molecular Weight:423.555
Hs Code.:

Synonyms:3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

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Chemical Property of 3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

There total 6 articles about 3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1343454-95-4
2-[3-(1-carboxy-1-methyl-ethylamino)-phenyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

: 593-51-1
methylamine hydrochloride

: 1343454-99-8
3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 25 ℃; for 12h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1343454-99-8
3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 5 h / 25 °C

3: triethylsilane; trifluoroacetic acid / 4 h / 25 °C

4: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 12 h / 120 °C

5: triethylamine; HATU / dichloromethane / 12 h / 25 °C

With triethylsilane; water; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; copper(l) iodide; ytterbium(III) trifluoromethanesulfonate nonohydrate; N,N-dimethylglycine hydrochoride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1343454-99-8
3,3-dimethyl-2-[3-{(1-methyl-1-(methylcarbamoyl)-ethyl)amino}-phenyl]-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Reflux

2: water / ytterbium(III) trifluoromethanesulfonate nonohydrate / tetrahydrofuran / 5 h / 25 °C

3: triethylsilane; trifluoroacetic acid / 4 h / 25 °C

4: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 12 h / 120 °C

5: triethylamine; HATU / dichloromethane / 12 h / 25 °C

With triethylsilane; water; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; copper(l) iodide; ytterbium(III) trifluoromethanesulfonate nonohydrate; N,N-dimethylglycine hydrochoride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;