4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Base Information

Chemical Name:4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene
CAS No.:1313189-54-6
Molecular Formula:C₂₆H₃₅BrOSSi₂
Molecular Weight:531.704
Hs Code.:

Synonyms:4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Suppliers and Price of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

There total 7 articles about 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 75-77-4
chloro-trimethyl-silane

: 1313189-34-2
3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene

: 1313189-54-6
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Guidance literature:: 3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100166

Reference yield:

: 29421-92-9
4-bromo-2-methylthiophene

: 1313189-54-6
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.05 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; bromine; potassium acetate; acetic acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166

Reference yield:

: 554-14-3
2-Methylthiophene

: 1313189-54-6
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methyl-3-trimethylsilylthiophene

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; perchloric acid / N,N-dimethyl-formamide / 50 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.05 h / -78 °C / Inert atmosphere

3.3: 1 h / -78 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 - 20 °C / Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; perchloric acid; bromine; potassium acetate; acetic acid; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166