ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

Base Information

Chemical Name:ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate
CAS No.:852233-58-0
Molecular Formula:C₃₁H₂₉N₅O₈
Molecular Weight:599.6
Hs Code.:

Synonyms:ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

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Chemical Property of ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

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Technology Process of ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

There total 11 articles about ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: ethyl [(2-benzyl-3-{[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]amino}-3-oxopropano-yl)amino]acetate

: 541-41-3
chloroformic acid ethyl ester

: 852233-58-0
ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

Guidance literature:: With triethylamine; In dichloromethane; at -10 - 20 ℃; for 0.5h;

Reference yield:

: 607367-17-9
2-benzyl-malonic acid benzyl ester methyl ester

: 852233-58-0
ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 62 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

5: 82 percent / hydroxylamine hydrochloride / methanol / 50 °C

6: 56 percent / triethylamine / CH₂Cl₂ / -10 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g

Reference yield:

: 852233-49-9
4-[(7-nitro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile

: 852233-58-0
ethyl 2-{[2benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-xodiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / H₂ / Pd/C / dimethylformamide / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 62 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

5: 82 percent / hydroxylamine hydrochloride / methanol / 50 °C

6: 56 percent / triethylamine / CH₂Cl₂ / -10 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g