4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole

Base Information

• Chemical Name: 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole
• CAS No.: 107195-18-6
• Molecular Formula: C₁₂H₁₅NS₂
• Molecular Weight: 237.39
• Mol file: 107195-18-6.mol

Synonyms:4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole

Chemical Property of 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole

There total 5 articles about 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyllithium (917-54-4) + 4,4-dimethyl-2-phenyl-1,3-thiazole-5(4H)-thione (81837-94-7) → methyl 2-methylpropanedithioate (5874-02-2) + 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole (107195-18-6)

Guidance literature:

With tertiary butyl chloride; In tetrahydrofuran; 1.) -78 deg C, 10 min, 2.) 5 min;

DOI:10.1002/hlca.19860690404

Reference yield: 68.0%

4,4-dimethyl-2-phenyl-1,3-thiazole-5(4H)-thione (81837-94-7) + methyl iodide (74-88-4) → 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole (107195-18-6)

Guidance literature:

4,4-dimethyl-2-phenyl-1,3-thiazole-5(4H)-thione; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

methyl iodide; In tetrahydrofuran;

DOI:10.1080/10426507.2015.1012201

Reference yield: 8.0%

oxirane (75-21-8,99932-75-9) + methyllithium (917-54-4) + 4,4-dimethyl-2-phenyl-1,3-thiazole-5(4H)-thione (81837-94-7) → 1-(2-Hydroxyethyl)thio-2-methyl-1-(methylthio)prop-1-en + 4,5-dihydro-4,4-dimethyl-5-(methylsulfanyl)-2-phenyl-1,3-thiazole (107195-18-6)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1002/hlca.19860690404

upstream raw materials:

oxirane

methyllithium

4,4-dimethyl-2-phenyl-1,3-thiazole-5(4H)-thione

methyl iodide