N-(1-Cyano-1-methylethyl)isobutyramide

Base Information

• Chemical Name: N-(1-Cyano-1-methylethyl)isobutyramide
• CAS No.: 84213-57-0
• Molecular Formula: C8H14 N2 O
• Molecular Weight: 154.212
• Hs Code.: 2926909090
• Mol file: 84213-57-0.mol

Synonyms:Propionamide,N-(1-cyano-1-methylethyl)-2-methyl- (6CI)

Chemical Property of N-(1-Cyano-1-methylethyl)isobutyramide

Chemical Property:

• Melting Point: 185-186 °C
• Boiling Point: 313.7±25.0 °C(Predicted)
• PKA: 13.12±0.46(Predicted)
• PSA: 56.38000
• Density: 0.961±0.06 g/cm3(Predicted)
• LogP: 1.90108

Purity/Quality:

98% ^*data from raw suppliers

N-(1-Cyano-1-methylethyl)isobutyramide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-Cyano-1-methylethyl)isobutyramide

There total 6 articles about N-(1-Cyano-1-methylethyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

isobutyryl chloride (79-30-1) + 2-amino-2-cyanopropane (19355-69-2) → N-(1-cyano-1-methylethyl)-2-methylpropanamide (84213-57-0)

Guidance literature:

With potassium carbonate; In ethyl acetate; at 20 ℃; for 72h;

DOI:10.1016/j.xphs.2019.05.012

Reference yield: 53.0%

2,2'-azobis(isobutyronitrile) (78-67-1) → Isobutyronitrile (78-82-0) + dimethyl-N-(2-cyano-2-propyl)ketenimine (10551-67-4) + 2,2,3,3-tetramethylsuccinonitrile (3333-52-6) + N-(1-cyano-1-methylethyl)-2-methylpropanamide (84213-57-0)

Guidance literature:

With silica gel; at 10 ℃; Product distribution; Irradiation; further in benzene, D-labelled, var. conditions of irradiation;

DOI:10.1039/c39820001106

Reference yield:

dimethyl-N-(2-cyano-2-propyl)ketenimine (10551-67-4) → N-(1-cyano-1-methylethyl)-2-methylpropanamide (84213-57-0)

Guidance literature:

hydrolysis;

DOI:10.1021/jo00175a005

upstream raw materials:

isobutyryl chloride

2-amino-2-cyanopropane

2-cyano-2-methylpropanoic acid

dimethyl-N-(2-cyano-2-propyl)ketenimine

Refernces

• 1、 Johnston, Linda J.,Mayo, Paul de,Wong, S. King. "Surface Photochemistry: Decomposition of Azobis(isobutyronitrile) on Dry Silica Gel". . p. 20 - 26. Retrieved 2007/10/02.