tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate
• CAS No.: 374795-03-6
• Molecular Formula: C₁₉H₂₉NO₄
• Molecular Weight: 335.444

Synonyms:tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

1-Boc-4-(hydroxymethyl)-4-[(benzyloxy)methyl]piperidine 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-tert-butyl 4-methyl 4-[(benzyloxy)methyl]piperidine-1,4-dicarboxylate → tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate (374795-03-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - -20 ℃; for 0.5h;

Reference yield: 40.0%

tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate (374794-84-0) + benzyl bromide (100-39-0) → tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate (374795-03-6)

Guidance literature:

With potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; at 10 - 20 ℃; for 16h;

Reference yield:

lithium aluminium tetrahydride (16853-85-3) + 1-tert-butyl 4-methyl 4-[(benzyloxy)methyl]piperidine-1,4-dicarboxylate → tert-butyl 4-[(benzyloxy)methyl]-4-(hydroxymethyl)piperidine-1-carboxylate (374795-03-6)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate

benzyl bromide

lithium aluminium tetrahydride

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Downstream raw materials:

1,1-dimethylethyl 4-ethenyl-4-(phenylmethoxymethyl)-1-piperidinecarboxylate

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