2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

Base Information

Chemical Name:2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]
CAS No.:1395322-87-8
Molecular Formula:C₁₅H₁₇FN₂O₄
Molecular Weight:308.309
Hs Code.:

Synonyms:2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

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Technology Process of 2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

There total 5 articles about 2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1395322-86-7
2-(2-fluoro-4-nitrophenyl)-5-oxohexahydrocyclopenta[c]pyrrole

: 107-21-1
ethylene glycol

: 1395322-87-8
2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

Guidance literature:: With toluene-4-sulfonic acid; In water; benzene; for 3h; Reflux; Inert atmosphere;
DOI:10.1111/j.1747-0285.2012.01404.x

Reference yield:

: 203663-25-6
t-butyl 5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenteno[c]pyrrole-2-carboxylate

: 1395322-87-8
2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / Reflux

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

4.1: toluene-4-sulfonic acid / water; benzene / 3 h / Reflux; Inert atmosphere

With hydrogenchloride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1111/j.1747-0285.2012.01404.x

Reference yield:

: 1417820-59-7,1323417-56-6
octahydro-5-hydroxycyclopenta[c]pyrrole hydrochloride

: 1395322-87-8
2-(2-fluoro-4-nitrophenyl)-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / Reflux

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: toluene-4-sulfonic acid / water; benzene / 3 h / Reflux; Inert atmosphere

With oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile; benzene;
DOI:10.1111/j.1747-0285.2012.01404.x