3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Base Information

Chemical Name:3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile
CAS No.:84186-24-3
Molecular Formula:C20H13 F N2 O
Molecular Weight:316.334
Hs Code.:
DSSTox Substance ID:DTXSID901170524
Mol file:84186-24-3.mol

Synonyms:3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile;84186-24-3;DTXSID901170524;STK711797;AKOS001738257;SR-01000521607;SR-01000521607-1;3-amino-1-(2-fluorophenyl)-1H-benzo[f]chromen-2-yl cyanide;3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile #;3-Amino-1-(2-fluorophenyl)-1H-naphtho[2,1-b]pyran-2-carbonitrile;1H-Naphtho[1,2-b]pyran-2-carbonitrile, 3-amino-1-(2-fluorophenyl)-

Suppliers and Price of 3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Chemical Property:

PSA：59.04000
LogP:4.89738
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:316.10119120
Heavy Atom Count:24
Complexity:565

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC3=C2C(C(=C(O3)N)C#N)C4=CC=CC=C4F

Technology Process of 3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile

There total 3 articles about 3-Amino-1-(2-fluorophenyl)-1H-benzo[f]chromene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 446-52-6
2-Fluorobenzaldehyde

: 135-19-3
β-naphthol

: 109-77-3
malononitrile

: 84186-24-3
2-amino-4-(2-fluorophenyl)-3-cyano-4H-naphtho<2,1-b>pyran

Guidance literature:: With 1,4?diazabicyclo[2.2.2]octane?1,4?diium hydrogen sulfate; In neat (no solvent); at 100 ℃; for 0.25h;
DOI:10.1007/s13738-018-1408-x

Reference yield: 69.0%

: 2698-43-3
2-(2-fluorobenzylidene)malononitrile

: 135-19-3
β-naphthol

: 84186-24-3
2-amino-4-(2-fluorophenyl)-3-cyano-4H-naphtho<2,1-b>pyran

Guidance literature:: With morpholine; In ethanol; Heating;

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 135-19-3
β-naphthol

: 84186-24-3
2-amino-4-(2-fluorophenyl)-3-cyano-4H-naphtho<2,1-b>pyran

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; water / 50 h / -20 - 20 °C

2: ethanol / 1 h / Reflux

In ethanol; water;
DOI:10.1134/S1070428013030147