3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

Base Information

Chemical Name:3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline
CAS No.:1253734-07-4
Molecular Formula:C₁₆H₇BrF₃N₃
Molecular Weight:378.151
Hs Code.:

Synonyms:3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

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Technology Process of 3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

There total 3 articles about 3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253734-06-3
5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

: 1253734-07-4
3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: With bromine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253734-07-4
3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; methanol / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3: potassium hydroxide; bromine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With methanol; phosphorus pentoxide; bromine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1253734-04-1
2,6-difluoro-N-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]benzamide

: 1253734-07-4
3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

2: potassium hydroxide; bromine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With phosphorus pentoxide; bromine; potassium hydroxide; In N,N-dimethyl-formamide;