[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

Base Information

Chemical Name:[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol
CAS No.:1026492-85-2
Molecular Formula:C₂₁H₂₃BrO₅S
Molecular Weight:467.381
Hs Code.:

Synonyms:[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

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Chemical Property of [3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

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Technology Process of [3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

There total 9 articles about [3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027533-14-7
3-(3-Bromo-4-methoxy-phenyl)-4-(4-methanesulfonyl-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid dimethyl ester

: 1026492-85-2
[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1021/jm950664x

Reference yield:

: 50413-24-6
2-bromo-1-(4-methanesulfonylphenyl)ethanone

: 1026492-85-2
[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 63.3 percent / K₂CO₃, KI / tetrahydrofuran / 6 h / Ambient temperature

2: K₂CO₃, KI / tetrahydrofuran

3: TiCl₃, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating

4: DIBAL / tetrahydrofuran / 0.25 h / -78 °C

With titanium(III) chloride; diisobutylaluminium hydride; potassium carbonate; potassium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/jm950664x

Reference yield:

: 1778-09-2
4-(Methylthio)acetophenone

: 1026492-85-2
[3-(3-Bromo-4-methoxy-phenyl)-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / mCPBA / CH₂Cl₂ / Ambient temperature

2: 15.7 g / HCl, bromine / acetic acid

3: 63.3 percent / K₂CO₃, KI / tetrahydrofuran / 6 h / Ambient temperature

4: K₂CO₃, KI / tetrahydrofuran

5: TiCl₃, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating

6: DIBAL / tetrahydrofuran / 0.25 h / -78 °C

With hydrogenchloride; titanium(III) chloride; bromine; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetic acid;
DOI:10.1021/jm950664x